Ammonia → 2-(4-Nitrophenyl)propanamide

HRID 1906227Notes

Reaction equation

HRID 1906227 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:15])[C:11](OC)=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH3:16]>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:15])[C:11]([NH2:16])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 3016521Methyl 2-(4-nitrophenyl)propionate

Product 1

HCID 50864052-(4-Nitrophenyl)propanamide

Procedure

A solution of methyl 2-(4-nitrophenyl)propionate (20.0 g) in aqueous ammonia (d=0.88, 350 ml) was stirred at room temperature for 36 h. The resultant solid was collected and dried in vacuo at 50° to give the title compound (13.4 g). A sample (0.1 g) was crystallised from water to give analytically pure material m.p. 120°-121°.

Workup

  1. customThe resultant solid was collected
  2. customdried in vacuo at 50°

Sources & evidence

ORD record
ord-758bb40fb29d4230ac09c60e0033830c
Source dataset
uspto-grants-1987_03
Patent number
US04650810

Reaction notes

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