HRID1906239

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCC/C=C/CCC(=O)NC1C(Oc2c3cc4cc2Oc2ccc(cc2Cl)C(OC2OC(CO)C(O)C(O)C2NC(C)=O)C2NC(=O)C(NC(=O)C4NC(=O)C4NC(=O)C(NC(=O)C(N)c5ccc(O)c(c5)Oc5cc4cc(O)c5C)C(O)c4ccc(c(Cl)c4)O3)c3ccc(O)c(c3)-c3c(OC4OC(CO)C(O)C(O)C4O)cc(O)cc3C(C(=O)OC)NC2=O)OC(CO)C(O)C1O

HCID16132315

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@@H]1[C@H](Oc2c3cc4cc2Oc2ccc(cc2Cl)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2NC(C)=O)[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H]4NC(=O)[C@@H](Cc5ccc(c(Cl)c5)O3)NC(=O)[C@H](N)c3ccc(O)c(c3)Oc3cc(O)cc4c3)c3ccc(O)c(c3)-c3c(O[C@H]4O[C@H](CO)[C@@H](O)[C@@H](O)[C@@H]4O)cc(O)cc3[C@@H](C(=O)O)NC2=O)O[C@@H](CO)[C@@H](O)[C@@H]1O

HCID73348316

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

2 次

PROCEDURE

实验过程

Teicoplanin A2 (10 g) is added to 1 N hydrochloric acid (150 ml) preheated to 80° C. while stirring. After about 45 minutes the reaction mixture is cooled to 0°-5° C. and 37% hydrochloric acid (30 ml) is added. Stirring is maintained for about 10 minutes, after which the precipitated solid is recovered by filtration, washed with 20 ml of 2 N HCl, then with ethyl ether, and dried overnight over potassium hydroxide pellets at room temperature, resulting in the crude product of the title (8.3 g).

WORKUP

后处理

custompreheated to 80° C.
temperatureAfter about 45 minutes the reaction mixture is cooled to 0°-5° C.
stirringStirring
temperatureis maintained for about 10 minutes
filtrationafter which the precipitated solid is recovered by filtration
washwashed with 20 ml of 2 N HCl
dry with materialwith ethyl ether, and dried overnight over potassium hydroxide pellets at room temperature

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-29db6b1240c341fc92036493f5165428
来源数据集: uspto-grants-1987_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04650855
来源说明: uspto-grants-1987_03

反应 SMILES

CCCCC/C=C/C[CH2:9][C:10]([NH:12][CH:13]1[CH:18]([O:19][C:20]2[C:25]3[O:26][C:27]4[CH:32]=[CH:31][C:30]([CH:33]([O:116][CH:117]5[O:122][CH:121]([CH2:123][OH:124])[CH:120]([OH:125])[CH:119]([OH:126])[CH:118]5[NH:127][C:128]([CH3:130])=[O:129])[CH:34]5[NH:54][C:52](=[O:53])[CH:51]([NH:55][C:56]([CH:58]6[NH:59][C:60]([CH:62]7[NH:95][C:93](=[O:94])[CH:82]([CH:83](O)[C:84]8[CH:90]=[CH:89][C:87]([O:88][C:21]=2[CH:22]=[C:23]6[CH:24]=3)=[C:86]([Cl:91])[CH:85]=8)[NH:81][C:79](=[O:80])[CH:78]([NH2:96])[C:76]2=[CH:77][C:72](=[C:73]([OH:97])[CH:74]=[CH:75]2)[O:71][C:65]2=[C:66](C)[C:67]([OH:69])=[CH:68][C:63]7=[CH:64]2)=[O:61])=[O:57])[C:49]2=[CH:50][C:45](=[C:46]([OH:98])[CH:47]=[CH:48]2)[C:44]2[C:39](=[CH:40][C:41]([OH:111])=[CH:42][C:43]=2[O:99][CH:100]2[O:105][CH:104]([CH2:106][OH:107])[CH:103]([OH:108])[CH:102]([OH:109])[CH:101]2[OH:110])[CH:38]([C:112]([O:114]C)=[O:113])[NH:37][C:35]5=[O:36])=[CH:29][C:28]=4[Cl:131])[O:17][CH:16]([CH2:132][OH:133])[CH:15]([OH:134])[CH:14]1[OH:135])=[O:11]>Cl>[CH3:9][C:10]([NH:12][C@@H:13]1[C@H:18]([O:19][C:20]2[C:25]3[O:26][C:27]4[CH:32]=[CH:31][C:30]([C@@H:33]([O:116][C@@H:117]5[O:122][C@@H:121]([CH2:123][OH:124])[C@@H:120]([OH:125])[C@H:119]([OH:126])[C@@H:118]5[NH:127][C:128]([CH3:130])=[O:129])[C@@H:34]5[NH:54][C:52](=[O:53])[C@H:51]([NH:55][C:56]([C@@H:58]6[NH:59][C:60]([C@H:62]7[NH:95][C:93](=[O:94])[C@@H:82]([CH2:83][C:84]8[CH:90]=[CH:89][C:87]([O:88][C:21]=2[CH:22]=[C:23]6[CH:24]=3)=[C:86]([Cl:91])[CH:85]=8)[NH:81][C:79](=[O:80])[C@H:78]([NH2:96])[C:76]2[CH:75]=[CH:74][C:73]([OH:97])=[C:72]([CH:77]=2)[O:71][C:65]2=[CH:64][C:63]7=[CH:68][C:67]([OH:69])=[CH:66]2)=[O:61])=[O:57])[C:49]2[CH:48]=[CH:47][C:46]([OH:98])=[C:45]([CH:50]=2)[C:44]2[C:43]([O:99][C@H:100]3[O:105][C@H:104]([CH2:106][OH:107])[C@@H:103]([OH:108])[C@@H:102]([OH:109])[C@@H:101]3[OH:110])=[CH:42][C:41]([OH:111])=[CH:40][C:39]=2[C@@H:38]([C:112]([OH:114])=[O:113])[NH:37][C:35]5=[O:36])=[CH:29][C:28]=4[Cl:131])[O:17][C@@H:16]([CH2:132][OH:133])[C@@H:15]([OH:134])[C@@H:14]1[OH:135])=[O:11]