反应详情

To a mixture of 1 g of 1-amino-4-(2-methoxyphenyl)piperazine and 1 ml of triethylamine was added 1.25 g of 4-chloro-3-sulfamoylbenzoyl chloride under stirring at room temperature. The reaction mixture was stirred at room temperature for 9 hours. The resulting precipitate was filtered, washed with water and recrystallized from ethanol to afford a title compound in a yield of 1.20 g (60%) as colorless needle crystals, mp 231°-233° C.

1. stirringThe reaction mixture was stirred at room temperature for 9 hours
2. filtrationThe resulting precipitate was filtered
3. washwashed with water
4. customrecrystallized from ethanol