Water → HCID 20213009, compound

HRID 1906247Notes

Reaction equation

HRID 1906247 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][NH2:9])[CH:5]=[C:4]([C:10]#[N:11])[CH:3]=1.[C:12](Cl)(=[O:14])[CH3:13].O>N1C=CC=CC=1>[C:12]([NH:9][NH:8][C:6]1[CH:5]=[C:4]([C:10]#[N:11])[CH:3]=[C:2]([Cl:1])[N:7]=1)(=[O:14])[CH3:13]

Participants

5

Reactant 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 13799476HCID 13799476, compound

Product 1

HCID 20213009HCID 20213009, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
0 °C

Procedure

A suspension of 5.0 g of 6-chloro-2-hydrazinopyridine-4-carbonitrile in 50 ml of pyridine was cooled to 0° C. in an ice bath and 3.1 g of acetyl chloride was added dropwise over a 10 minute period. The mixture became homogeneous after the addition and it was allowed to warm to ambient temperature. After 2 hours, the reaction mixture was poured into 180 ml of water and the precipitate which formed was separated by filtration and dried to give N-acetyl-N'-(6-chloro-4-cyano-2-pyridyl)hydrazine which was purified by recrystallization from ethanol.

Workup

  1. additionafter the addition and it
  2. temperatureto warm to ambient temperature
  3. customthe precipitate which formed
  4. customwas separated by filtration
  5. customdried

Sources & evidence

ORD record
ord-da48261b9fe440c0b6af20f085874e05
Source dataset
uspto-grants-1987_03
Patent number
US04650872

Reaction notes

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