反应详情

4.0 g of (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetic acid, 80 ml of absolute tetrahydrofuran and 5 ml of acetyl chloride are boiled at reflux for 4 hours while stirring. Thereafter, the mixture is evaporated. The residue is filtered through silica gel (granular size 0.2-0.5 mm). The evaporation residue of the fractions which are eluted with ethyl acetate is stirred in diethyl ether. By filtration there is isolated (R/S)-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetic acid of melting point 95°-96°.

1. temperatureat reflux for 4 hours
2. customThereafter, the mixture is evaporated
3. filtrationThe residue is filtered through silica gel (granular size 0.2-0.5 mm)
4. washThe evaporation residue of the fractions which are eluted with ethyl acetate
5. stirringis stirred in diethyl ether
6. filtrationBy filtration