HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (+-)- → (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (+-)- | HCID 3069854 | — |
| Reactant | ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrroldinyl)propionate | HCID 76485496 | — |
| Product | (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionamide | HCID 54458868 | — |
Reaction Steps
According to the process described in paragraph (b) of Example 1, from ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionate there is obtained, after chromatographic filtration on silica gel (granular size 0.2-0.5 mm), elution with acetonitrile/ethanol (1:1) and crystallization from acetonitrile, (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionamide of melting point 139°-141°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650878 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-3f1b8e71da46452fac7b59ae61b9b4a4 |
| Source note | uspto-grants-1987_03 |