HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | cis-(+-)-N-(2-(2,6-Dimethyl-1-piperidinyl)ethyl)-2-oxo-3-hydroxy-1-pyrrolidineacetamide | HCID 3069833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide hydrochloride | HCID 131713899 | — |
Reaction Steps
2.97 g of (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide are dissolved in 10 ml of ethanol. Thereto there are added 1.26 ml of a 7.93N solution of hydrogen chloride in ethanol. Thereupon, the mixture is evaporated and the residue is dried in a high vacuum. There is obtained (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide hydrochloride which has a decomposition point of 97°. The microanalysis shows the following values:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650878 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-a6d7c60fe0f844af83770555c56644e4 |
| Source note | uspto-grants-1987_03 |