Hydrochloric Acid → (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide hydrochloride

HRID 1906291Notes

Reaction equation

HRID 1906291 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:9][CH2:10][NH:11][C:12](=[O:21])[CH2:13][N:14]1[CH2:18][CH2:17][CH:16]([OH:19])[C:15]1=[O:20].[ClH:22]>C(O)C>[ClH:22].[CH3:8][C@H:4]1[CH2:5][CH2:6][CH2:7][C@@H:2]([CH3:1])[N:3]1[CH2:9][CH2:10][NH:11][C:12](=[O:21])[CH2:13][N:14]1[CH2:18][CH2:17][CH:16]([OH:19])[C:15]1=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3069833cis-(+-)-N-(2-(2,6-Dimethyl-1-piperidinyl)ethyl)-2-oxo-3-hydroxy-1-pyrrolidineacetamide

Product 1

HCID 131713899(R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2.97 g of (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide are dissolved in 10 ml of ethanol. Thereto there are added 1.26 ml of a 7.93N solution of hydrogen chloride in ethanol. Thereupon, the mixture is evaporated and the residue is dried in a high vacuum. There is obtained (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide hydrochloride which has a decomposition point of 97°. The microanalysis shows the following values:

Workup

  1. customThereupon, the mixture is evaporated
  2. customthe residue is dried in a high vacuum

Sources & evidence

ORD record
ord-a6d7c60fe0f844af83770555c56644e4
Source dataset
uspto-grants-1987_03
Patent number
US04650878

Reaction notes

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