Diisopropylamine → HCID 20213089, compound

HRID 1906309Notes

Reaction equation

HRID 1906309 reaction equation
[C:1]([C:3]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:4]([CH3:8])[C:5](Cl)=[O:6])#[N:2].[CH:21]([NH:24][CH:25]([CH3:27])[CH3:26])([CH3:23])[CH3:22].C(C(C1C=CC=CC=1)(C1C=CC=CC=1)C(CC)C(N(C)C)=O)#N>O>[C:1]([C:3]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:4]([CH3:8])[C:5]([N:24]([CH:25]([CH3:27])[CH3:26])[CH:21]([CH3:23])[CH3:22])=[O:6])#[N:2]

Participants

5

Reactant 3

HCID 7912DiisopropylamineHCID 20213064HCID 20213064, compoundHCID 20213092HCID 20213092, compound

Product 1

HCID 20213089HCID 20213089, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.1 Mol of 3-cyano-3,3-diphenyl-2-methylpropionyl chloride were added dropwise while cooling and stirring to 50 g (0.5 mol) of diisopropylamine. The mixture was left standing at room temperature overnight and heated at 40°-50° C. for 30 minutes. The mixture was poured into water and isolated as described above for the preparation of 3-cyano-3,3-diphenyl-2-ethyl-N,N-dimethyl-propanamide. The amide was crystallized from a mixture of toluen and ether. Yield: 25 g (50%), melting at 195°-205° C.

Workup

  1. temperaturewhile cooling
  2. waitThe mixture was left
  3. temperatureheated at 40°-50° C. for 30 minutes
  4. customisolated
  5. customThe amide was crystallized from a mixture of toluen and ether

Sources & evidence

ORD record
ord-80b2819268ad4fdfada328f53df8a627
Source dataset
uspto-grants-1987_03
Patent number
US04650900

Reaction notes

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