Triethylamine → HCID 13823415, compound

HRID 1906372Notes

Reaction equation

HRID 1906372 reaction equation
[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[SH:13].Cl[Sn:15]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(N(CC)CC)C>C(Cl)Cl>[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:13][Sn:15]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12540Triphenyltin ChlorideHCID 178481666HCID 178481666, compound

Product 1

HCID 13823415HCID 13823415, compoundYield 61.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 11.6 g (0.06 mole) 3-methyl-2-mercapto-4(3H)-quinazolinone, 23.2 g (0.06 mole) chlorotriphenyl tin and 6.1 g (0.06 mole) triethylamine in methylene chloride (about 200 ml) were stirred together, then refluxed for four hours and stirred overnight. The reaction mixture was washed with water, dried and stripped. After trituration with ether, 20.0 g of the above-identified product as a white solid, melting point 155°-157° C. was obtained.

Workup

  1. temperaturerefluxed for four hours
  2. stirringstirred overnight
  3. washThe reaction mixture was washed with water
  4. customdried

Sources & evidence

ORD record
ord-8ee265cb130a464b841faf800796c631
Source dataset
uspto-grants-1987_03
Patent number
US04652558

Reaction notes

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