Triethylamine → HCID 13799828, compound

HRID 1906377Notes

Reaction equation

HRID 1906377 reaction equation
Cl.[NH2:2][C:3]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)([CH3:6])[C:4]#[N:5].C(N(CC)CC)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[S:9]1[CH:10]=[CH:11][C:7]([C:3]([NH:2][S:20]([CH3:19])(=[O:22])=[O:21])([CH3:6])[C:4]#[N:5])=[CH:8]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 20211708HCID 20211708, compound

Product 1

HCID 13799828HCID 13799828, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 2.7 g (0.0143 mole) 2-amino-2-(3-thienyl)-propionitrile hydrochloride (the product of Example 8) in 50 ml methylene chloride, 3.6 g (5 ml [0.036 mole]) triethylamine were added, followed by 2 g (1.4 ml [0.018 mole]) methanesulfonyl chloride. The reaction mixture was stirred at room temperature for three hours. The reaction mixture was then washed with saturated sodium bicarbonate and brine, dried over sodium sulfate and stripped to give the above-identified product which was used in Example 10 without further purification.

Workup

  1. washThe reaction mixture was then washed with saturated sodium bicarbonate and brine
  2. dry with materialdried over sodium sulfate
  3. customto give the above-identified product which
  4. customwas used in Example 10 without further purification

Sources & evidence

ORD record
ord-258c58a4b7d2441f9d90db48982c6c9d
Source dataset
uspto-grants-1987_03
Patent number
US04652556

Reaction notes

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