Triethylamine → HCID 13799782, compound

HRID 1906394Notes

Reaction equation

HRID 1906394 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][S:5](Cl)(=[O:7])=[O:6].[NH2:9][C:10]([CH3:14])([CH3:13])[C:11]#[N:12].C(N(CC)CC)C>C(Cl)Cl>[CH3:13][C:10]([NH:9][S:5]([CH2:4][CH2:3][CH2:2][Cl:1])(=[O:7])=[O:6])([CH3:14])[C:11]#[N:12]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 154103-Chloropropanesulphonyl chlorideHCID 880222-Amino-2-methylpropionitrile

Product 1

HCID 13799782HCID 13799782, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred mixture of 9.90 g (0.05 mole) 3-chloropropane sulfonyl chloride and 4.71 g (0.056 mole) 2-amino-2-methyl-propionitrile in 100 ml methylene chloride at 0° C., 5.66 g (0.056 mole) triethylamine as a 10% solution in methylene chloride was added very slowly. The reaction mixture was allowed to stir overnight in the gradually melting ice bath. The reaction mixture was washed three times with 50 ml water. The organic layer was dried over calcium sulfate and evaporated to give 9.90 g of the above-identified product as a brown oil.

Workup

  1. washThe reaction mixture was washed three times with 50 ml water
  2. dry with materialThe organic layer was dried over calcium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-713009c3297d4ce6b18085c91542da66
Source dataset
uspto-grants-1987_03
Patent number
US04652556

Reaction notes

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