反应详情

There was dissolved 2.6 g (0.01 mole) of 7-(2,3-epoxypropoxy)-2-ethoxycarbonylbenzofuran obtained in Reference Example 9 in 10 ml of ethanol, and thereto 0.9 g (0.012 mole) of potassium hydroxide in 5 ml of ethanol solution was added dropwise with stirred under cooling with ice. After stirring the mixture for 3 hours the reaction was completed to neutralize the reaction mixture by 2N hydrochloric acid. Thereafter, the solvent was distilled away from the reaction mixture under reduced pressure, the resultant residue was extracted from 30 ml of chloroform. After washing the chloroform layer with water the layer was dried with magnesium sulfate, and then chloroform was distilled away under reduced pressure to give the resultant residue.

1. temperatureunder cooling with ice
2. stirringAfter stirring the mixture for 3 hours the reaction
3. distillationThereafter, the solvent was distilled away from the reaction mixture under reduced pressure
4. extractionthe resultant residue was extracted from 30 ml of chloroform
5. washAfter washing the chloroform layer with water the layer
6. dry with materialwas dried with magnesium sulfate
7. distillationchloroform was distilled away under reduced pressure