1-(o-Tolyl)piperazine hydrochloride → 2-Carbamoyl-7-{2-hydroxy-3-[4-(2-methylphenyl)piperazinyl]propoxy}benzofuran

HRID 1906442Notes

Reaction equation

HRID 1906442 reaction equation
[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2].Cl.[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][N:29]3[CH2:30][CH2:31][N:26]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=4[CH3:19])[CH2:27][CH2:28]3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 122278951-(o-Tolyl)piperazine hydrochlorideHCID 137294032-Carbamoyl-7-(2,3-epoxypropoxy)benzofuran

Product 1

HCID 137293852-Carbamoyl-7-{2-hydroxy-3-[4-(2-methylphenyl)piperazinyl]propoxy}benzofuran

Procedure

The procedures of Example 10 were repeated except that 1.2 g (0.005 mole) of 2-carbamoyl-7-(2,3-epoxypropoxy)benzofuran and 1.2 g (0.0055 mole) of 1-(2-methylphenyl)piperazine hydrochloride were employed. The obtained concentrated residue was crystallized from ethyl acetate and petroleum ether.

Workup

  1. customThe obtained concentrated residue was crystallized from ethyl acetate and petroleum ether

Sources & evidence

ORD record
ord-c920629ff2c34bcbb35aacb3fe1b01e1
Source dataset
uspto-grants-1987_03
Patent number
US04652566

Reaction notes

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