Hydrochloric Acid → HCID 70430444, compound

HRID 1906471Notes

Reaction equation

HRID 1906471 reaction equation
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10][NH:11][C:12]1[C:17]([C:18]([O:20]CC)=[O:19])=[C:16]2[CH2:23][CH2:24][CH2:25][C:15]2=[CH:14][N:13]=1.[ClH:26]>>[ClH:26].[ClH:26].[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10][NH:11][C:12]1[C:17]([C:18]([OH:20])=[O:19])=[C:16]2[CH2:23][CH2:24][CH2:25][C:15]2=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20212026HCID 20212026, compound

Product 1

HCID 70430444HCID 70430444, compoundYield 38%

Procedure

2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-3-carbethoxy-4,5-propanopyridine (15.0 g, 41.7 m.mole) and concentrated hydrochloric acid (36% w/v, 250 ml) were refluxed for 21 hours. The solution was evaporated to dryness in vacuo, ethanol being added to assist in removal of the water. The residue was rinsed with methanol and isopropanol and dried to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]4,5-propanopyridine 3-carboxylic acid dihydrochloride (6.47 g, 38% yield; m.p. 208.5°-209°).

Workup

  1. customThe solution was evaporated to dryness in vacuo, ethanol being
  2. additionadded
  3. customto assist in removal of the water
  4. washThe residue was rinsed with methanol and isopropanol
  5. customdried

Sources & evidence

ORD record
ord-ce50efbc003f46af8244e871f471d9f4
Source dataset
uspto-grants-1987_03
Patent number
US04652572

Reaction notes

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