Hydrochloric Acid → HCID 178525857, compound

HRID 1906594Notes

Reaction equation

HRID 1906594 reaction equation
C([O:3][C:4](=[O:12])[CH2:5][N:6]1[C:10](Cl)=[N:9][N:8]=[N:7]1)C.NC(N)=[S:15].O.Cl>C(O)C>[SH:15][C:10]1[N:6]([CH2:5][C:4]([OH:3])=[O:12])[N:7]=[N:8][N:9]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2723790ThioureaHCID 127857925-Chloro-1H-tetrazole-1-acetic acid ethyl ester

Product 1

HCID 178525857HCID 178525857, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a 500 ml round flash equipped with agitator, relux condenser, thermometer and a dropping funnel a mixture of 100 g (0.52 mol) 5-Chloro-1H-tetrazole-1-acetic acid ethyl ester, 44 g (0,57 Mol) thiourea, 210 g water and 25 g of 38 wt.% aqueous hydrochloric acid was heated to reflux for 6 hours, while the ethanol formed during the reaction was distilled off. For working up purpose, the residue was extracted with methyl isobutyl ketone. After evaporation of the ketone 57.9 g=69% of the theory of a white crystalline solid (melting point 173° C.) of 5-Mercapto-1H-tetrazole-1-acetic acid was obtained (purity 99%).

Workup

  1. customIn a 500 ml round flash equipped with agitator, relux condenser
  2. temperaturewas heated
  3. customformed during the reaction
  4. distillationwas distilled off
  5. extractionthe residue was extracted with methyl isobutyl ketone
  6. customAfter evaporation of the ketone 57.9 g=69% of the theory of a white crystalline solid (melting point 173° C.) of 5-Mercapto-1H-tetrazole-1-acetic acid
  7. customwas obtained (purity 99%)

Sources & evidence

ORD record
ord-4a0ee8bf7b934a50ae3f5ac7a7555d7c
Source dataset
uspto-grants-1987_03
Patent number
US04652671

Reaction notes

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