反应详情

A mixture of 6-[4-(3-benzylaminopropionamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (5.5 g; 0.015 mol), 1-[2-allyl-4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-2,3-epoxypropane (8.65 g; 0.03 mol) and n-propanol (100 ml) was stirred under reflux for 24 hours. The mixture was cooled, filtered and the filtrate was evaporated under reduced pressure and chromatographed on a silica gel column, using ethyl acetate as eluant, to give as a glass 6-[4-[3-[2-hydroxy-3-[2-allyl-4-(2-(cyclopropylmethoxy)ethyl)phenoxy]-N-benzylpropylamino]propionamido]phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (4.4 g).

1. temperatureunder reflux for 24 hours
2. temperatureThe mixture was cooled
3. filtrationfiltered
4. customthe filtrate was evaporated under reduced pressure
5. customchromatographed on a silica gel column