反应详情

1-[4-(2-Cyclopropylmethoxyethyl)phenoxy]-2,3-epoxypropane (10 g) and benzylamine (13 g) were stirred under reflux, in n-propanol (100 ml) for 20 hours. The mixture was cooled and evaporated under reduced pressure to give a residue. This was stirred under petroleum ether (60°-80°) for 30 minutes; the solvent was decanted and the residue triturated with further petroleum ether. A white solid was obtained, collected by filtration and recrystallised from acetonitrile to afford N-benzyl-3-[4-(2-(cyclopropylmethoxy)ethyl)phenoxy]-2-hydroxypropylamine (8.8 g), m.p. 75°-6° C.

1. temperatureThe mixture was cooled
2. customevaporated under reduced pressure
3. customto give a residue
4. customthe solvent was decanted
5. customthe residue triturated with further petroleum ether
6. customA white solid was obtained
7. filtrationcollected by filtration
8. customrecrystallised from acetonitrile