4-Propanoylanisole → HCID 20210193, compound

HRID 1906704Notes

Reaction equation

HRID 1906704 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:12])[CH2:10][CH3:11])=[CH:5][CH:4]=1>[Ru].CO>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([CH:9]([OH:12])[CH2:10][CH3:11])[CH2:5][CH2:4]1

Participants

4

Reactant 1

HCID 671444-Propanoylanisole

Product 1

HCID 20210193HCID 20210193, compound

Reagents, catalysts & solvents 2

HCID 23950RutheniumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 100 g of p-methoxypropiophenone, 250 ml of methanol and 5 g of a 5% strength ruthenium/active carbon catalyst was hydrogenated at 120° C. and under 150 bar until absorption of hydrogen was virtually complete. The catalyst was removed, the solvent was distilled off under 1013 mbar and the residue was then fractionated. 92 g of a colorless liquid having a boiling point of 73°-75° C. 0.01 mbar and a fine woody note were obtained.

Workup

  1. customwas hydrogenated at 120° C. and under 150 bar until absorption of hydrogen
  2. customThe catalyst was removed
  3. distillationthe solvent was distilled off under 1013 mbar
  4. custom0.01 mbar and a fine woody note were obtained

Sources & evidence

ORD record
ord-fb392a6c51a243838e27d7d64eba6a3b
Source dataset
uspto-grants-1987_03
Patent number
US04654167

Reaction notes

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