Iodoethane → 2-[4-(Ethylsulfanyl)-2-methoxyphenyl]-1H-imidazo[4,5-d]pyridazine

HRID 1906738Notes

Reaction equation

[SH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]3[C:15]([N:16]=2)=[CH:14][N:13]=[N:12][CH:11]=3)=[C:4]([O:17][CH3:18])[CH:3]=1.[CH2:19](I)[CH3:20]>>[CH3:18][O:17][C:4]1[CH:3]=[C:2]([S:1][CH2:19][CH3:20])[CH:7]=[CH:6][C:5]=1[C:8]1[NH:9][C:10]2[C:15]([N:16]=1)=[CH:14][N:13]=[N:12][CH:11]=2

Participants

Reactant 2

HCID 6340Iodoethane

HCID 136017172HCID 136017172, compound

Product 1

HCID 132324742-[4-(Ethylsulfanyl)-2-methoxyphenyl]-1H-imidazo[4,5-d]pyridazine

Procedure

In a manner similar to that of Example 12, conversion of 2-(4-mercapto-2-methoxyphenyl)-1,3,5,6-tetraazaindene into the Na salt and subsequent reaction with ethyl iodide gives 2-(2-methoxy-4-ethylthiophenyl)-1,3,5,6-tetraazaindene, m.p. 248°.

Sources & evidence

ORD record: ord-85d16c206d4a42eeb769e3c4e2891a56
Source dataset: uspto-grants-1987_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04654344

Reaction notes

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