2-Fluorobenzylamine → N-[(2-Fluorophenyl)methyl]-3-methyl-3H-imidazo[4,5-c]pyridin-4-amine

HRID 1906741Notes

Reaction equation

HRID 1906741 reaction equation
Cl[C:2]1[C:7]2[N:8]([CH3:11])[CH:9]=[N:10][C:6]=2[CH:5]=[CH:4][N:3]=1.[F:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16]>>[F:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH:16][C:2]1[C:7]2[N:8]([CH3:11])[CH:9]=[N:10][C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 666492-FluorobenzylamineHCID 202107464-Chloro-3-methyl-3H-imidazo[4,5-c]pyridine

Product 1

HCID 13264455N-[(2-Fluorophenyl)methyl]-3-methyl-3H-imidazo[4,5-c]pyridin-4-amine

Procedure

A mixture of 16.76 g of 4-chloro-3-methyl-3H-imidazo(4,5-c)pyridine and 30 g of o-fluorobenzylamine is melted at 180° for 2 hours. After customary working up, 4-o-fluorobenzylamino-3-methyl-3H-imidazo-(4,5-c)pyridine of m.p. 163°-164° is obtained.

Workup

  1. customfor 2 hours

Sources & evidence

ORD record
ord-271e549f45f94e2eaa21031df034a36f
Source dataset
uspto-grants-1987_03
Patent number
US04654350

Reaction notes

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