Phenyl isocyanate → HCID 20210822, compound

HRID 1906746Notes

Reaction equation

HRID 1906746 reaction equation
[OH:1][CH2:2][CH:3]([CH2:18][OH:19])[CH:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][CH2:6][NH:5]1.[C:20]1([N:26]=[C:27]=[O:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[C:20]1([NH:26][C:27]([O:1][CH2:2][CH:3]([CH2:18][O:19][C:27](=[O:28])[NH:26][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:4]2[C:13]3[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=3)[CH2:7][CH2:6][N:5]2[C:27](=[O:28])[NH:26][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 136966832-(6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-propane-1,3-diol

Product 1

HCID 20210822HCID 20210822, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.01 mole of 1-[bis(hydroxymethyl)-methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline is reacted with 0.03 mole of phenylisocyanate in toluene, as described in Example 22. The aimed compound is obtained, which has the same physical and analytical characteristics as the product of Example 26 (Table 2).

Sources & evidence

ORD record
ord-d9efaae26a61442b9b18955a503bccda
Source dataset
uspto-grants-1987_03
Patent number
US04654351

Reaction notes

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