Butyl bromide → HCID 178454952, compound

HRID 1906763Notes

Reaction equation

HRID 1906763 reaction equation
[CH3:1][N:2]1[C:11]([OH:12])=[C:5]2[N:6]=[CH:7][N:8]=[C:9]([SH:10])[C:4]2=[N:3]1.[CH2:13](Br)[CH2:14][CH2:15][CH3:16]>N>[CH3:1][N:2]1[C:11]([OH:12])=[C:5]2[N:6]=[CH:7][N:8]=[C:9]([S:10][CH2:13][CH2:14][CH2:15][CH3:16])[C:4]2=[N:3]1

Participants

4

Reactant 2

HCID 8002Butyl bromideHCID 178481720HCID 178481720, compound

Product 1

HCID 178454952HCID 178454952, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

1.2 g of 2-methyl-3-hydroxy-7-mercapto-pyrazolo [4,3-d]pyrimidine was dissolved in 50 ml of aqueous ammonia, and after an addition of 1.08 g of n-butyl bromide, the mixture was stirred at room temperature for 5 hours. By means of a rotary evaporator, ammonia gas was distilled off at room temperature. Then, the aqueous solution was acidified with hydrochloric acid and extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate, and then evaporated to dryness. The remaining solid was recrystallized from acetone.

Workup

  1. customBy means of a rotary evaporator, ammonia gas
  2. distillationwas distilled off at room temperature
  3. extractionextracted with chloroform
  4. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
  5. customevaporated to dryness
  6. customThe remaining solid was recrystallized from acetone

Sources & evidence

ORD record
ord-37a55e4dcd684f3482554320918708ff
Source dataset
uspto-grants-1987_03
Patent number
US04654348

Reaction notes

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