反应详情

温度

0 °C

A solution of thionyl chloride (0.03 ml, 0.054 g, 0.45 mmol) in dry dichloromethane (5 ml) was added dropwise to a stirred solution of 1-benzyl-3-phenylsulfinylindole (0.150 g, 0.45 mmol) in dry dichloromethane (20 ml), containing suspended sodium bicarbonate (1 g), maintained at 0° C. One half hour after the addition was completed the reaction was quenched with a saturated solution of aqueous sodium bicarbonate. The organic phase was separated, combined with a dichloromethane extract of the aqueous phase and the combined organic phases were dried and evaporated in vacuo. Crystallization of the residue from dichloromethane/hexane gave the title product.

1. additioncontaining
2. additionOne half hour after the addition
3. customwas quenched with a saturated solution of aqueous sodium bicarbonate
4. customThe organic phase was separated
5. extractionextract of the aqueous phase
6. customthe combined organic phases were dried
7. customevaporated in vacuo
8. customCrystallization of the residue from dichloromethane/hexane