Benzyl Alcohol → 1-(4-Carbobenzyloxyphenyl)propan-2-one

HRID 1906962Notes

Reaction equation

HRID 1906962 reaction equation
[CH2:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3].[CH2:14]([OH:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1C=CC=CC=1>[C:9]([C:8]1[CH:12]=[CH:13][C:5]([CH2:1][C:2](=[O:3])[CH3:4])=[CH:6][CH:7]=1)([O:21][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10]

Participants

4

Reactant 2

HCID 244Benzyl AlcoholHCID 201341784-(2-Oxopropyl)benzoyl chloride

Product 1

HCID 201342441-(4-Carbobenzyloxyphenyl)propan-2-one

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

4-Acetonylbenzoyl chloride (3.92 g) and benzyl alcohol (2.16 g) were refluxed in benzene for 4 hours and then left at room temperature for 48 hours. Removal of the solvent gave the title compound. τ (CDCl3) 7.9 (3H, s), 6.32 (2H, s), 4.69 (2H, s), 2.78 (2H, d, J=8 Hz), 2.70 (5H, m), 1.99 (2H, d, J=8 Hz).

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-2db79194f9a0468fafca77f60109b1f9
Source dataset
uspto-grants-1987_03
Patent number
US04654371

Reaction notes

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