HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1907010Generated: October 30, 2026
Methanol → 2-(6-Methoxy-2-naphthyl)propionic acid
https://huagongshe.com/reaction/1907010
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1,1-Dimethoxy-1-(6-methoxy-2-naphthyl)prop-2-yl methanesulfonate | HCID 12756330 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(6-Methoxy-2-naphthyl)propionic acid | HCID 1302 | 102.9% |
Reaction Steps
A mixture containing 1.6 g of 1,1-dimethoxy-1-(6-methoxy-2-naphthyl)prop 2-yl methanesulfonate, 1.5 g of sodium bicarbonate, 10 ml of water and 10 ml of methanol is heated at 70° C. with refluxing for 11/2 hours. Then the reaction mixture is cooled and poured into water and extracted with ether. The ethereal extract is dried over magnesium sulfate and evaporated under reduced pressure to yield 1.07 g of 2-(6-methoxy-2-naphthyl)propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04654438 |
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| Source dataset | uspto-grants-1987_03 |
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| ORD ID | ord-be5114891ccf40c48c30785e4945b5c3 |
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| Source note | uspto-grants-1987_03 |
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