1-Methylpiperazine → HCID 178480622, compound

HRID 1907232Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[C:7]([C:12](=[O:21])[N:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:14]=3)=[CH:8][NH:9][C:10]=2[CH:11]=1.[CH3:22][N:23]1[CH2:28][CH2:27]N[CH2:25][CH2:24]1>>[CH3:22][N:23]1[CH2:28][CH2:27][N:1]([C:2]2[CH:3]=[CH:4][C:5]3[C:6]4[C:7]([C:12](=[O:21])[N:13]([C:15]5[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=5)[N:14]=4)=[CH:8][NH:9][C:10]=3[CH:11]=2)[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 178507229HCID 178507229, compound

Product 1

HCID 178480622HCID 178480622, compound

Procedure

The title compound was prepared following the procedure in Step 5 using 13a and 1-methylpiperazine. 1H-NMR (CD3OD) δ (ppm): 2.44 (3H, s), 2.74 (4H, brm), 3.44 (4H, brm), 7.03 (1H, d, J=2.20 Hz), 7.27 (1H, ddd, J=7.41, 1.64, 1.10 Hz), 7.35 (1H, dd, J=9.07, 2.47 Hz), 7.65 (2H, m), 7.99 (2H, m), 8.17 (1H, d, J=9.07 Hz), 8.53 (1H, s). m/z 360.4 (MH+).

Sources & evidence

ORD record: ord-9c2daea08049461dbbf1b9a005ee93c8
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598159B2

Reaction notes

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