1-Methylpiperazine → HCID 178480617, compound

HRID 1907253Notes

Reaction equation

HRID 1907253 reaction equation
FC1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=CC2NC=C3C(=O)N(C4C=CC=CC=4)N=C3C=2C=1.F[C:29]1[C:30]([F:48])=[CH:31][C:32]2[C:33]3[C:34]([C:39](=[O:47])[N:40]([C:42]4[CH:46]=[CH:45][S:44][CH:43]=4)[N:41]=3)=[CH:35][NH:36][C:37]=2[CH:38]=1.CN1CCNCC1>>[F:48][C:30]1[C:29]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)=[CH:38][C:37]2[NH:36][CH:35]=[C:34]3[C:39](=[O:47])[N:40]([C:42]4[CH:46]=[CH:45][S:44][CH:43]=4)[N:41]=[C:33]3[C:32]=2[CH:31]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 178515220HCID 178515220, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178480617HCID 178480617, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27d and 1-methylpiperazine. 1H-NMR (DMSO-d6) δ (ppm): 2.28 (3H, s), 2.64 (4H, brm), 3.22 (4H, brm), 7.21 (1H, m), 7.58 (1H, m), 7.79 (3H, m), 8.67 (1H, m). m/z 384.2

Sources & evidence

ORD record
ord-ea723c64b2eb433a9fdb9c073ffae184
Source dataset
uspto-grants-2013_12
Patent number
US08598159B2

Reaction notes

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