Methyl iodide → (R)-1-(4-Fluorophenyl)-4a-methoxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester

HRID 1907290Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:17][CH2:16][C:15]2[C@:10]([CH2:28][OH:29])([CH2:11][C:12]3[CH:20]=[N:19][N:18]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=4)[C:13]=3[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].I[CH3:31]>>[C:1]([O:5][C:6]([N:8]1[CH2:17][CH2:16][C:15]2[C@:10]([CH2:28][O:29][CH3:31])([CH2:11][C:12]3[CH:20]=[N:19][N:18]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=4)[C:13]=3[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 66780366(R)-1-(4-fluorophenyl)-4a-hydroxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester

Product 1

HCID 66779665(R)-1-(4-Fluorophenyl)-4a-methoxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared by the method of Preparation 2b using (R)-1-(4-fluoro-phenyl)-4a-hydroxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester and iodomethane. 1H NMR (CDCl3): δ 7.47-7.40 (m, 3H), 7.19-7.12 (m, 2H), 6.32-6.29 (d, 1H, J=2.2 Hz), 4.45-4.30 (d, 1H, J=14 Hz), 4.27-3.92 (bs, 1H), 3.29 (s, 3H), 3.19-3.13 (d, 1H, J=9.1 Hz), 3.09-2.97 (d, 2H, J=16 Hz), 2.92-2.65 (m, 2H), 2.59-2.46 (m, 1H), 2.40-2.20 (m, 2H), 1.49 (s, 9H).

Sources & evidence

ORD record: ord-418acc92d6cf45aca9f56ca7fdbc4fd9
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598154B2

Reaction notes

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