Methyl iodide → (R)-1-(4-Fluorophenyl)-4a-methoxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester

Participants

Reaction Steps

The title compound was prepared by the method of Preparation 2b using (R)-1-(4-fluoro-phenyl)-4a-hydroxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester and iodomethane. 1H NMR (CDCl3): δ 7.47-7.40 (m, 3H), 7.19-7.12 (m, 2H), 6.32-6.29 (d, 1H, J=2.2 Hz), 4.45-4.30 (d, 1H, J=14 Hz), 4.27-3.92 (bs, 1H), 3.29 (s, 3H), 3.19-3.13 (d, 1H, J=9.1 Hz), 3.09-2.97 (d, 2H, J=16 Hz), 2.92-2.65 (m, 2H), 2.59-2.46 (m, 1H), 2.40-2.20 (m, 2H), 1.49 (s, 9H).

Provenance & Evidence