[3-(Tetrahydro-pyran-2-yloxy)-cyclobutyl]-methanol → HCID 66779384, compound

HRID 1907326Notes

Reaction equation

HRID 1907326 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[C:14]4[C@:19]([C:21](Cl)=[O:22])([CH2:20][C:11]=3[CH:10]=[N:9]2)[CH2:18][N:17]([S:24]([C:27]2[CH:28]=[N:29][C:30]([N:33]3[CH2:37][CH2:36][C@@H:35]([F:38])[CH2:34]3)=[CH:31][CH:32]=2)(=[O:26])=[O:25])[CH2:16][CH2:15]4)=[CH:4][CH:3]=1.[O:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH:40]1[O:45][CH:46]1[CH2:49][CH:48]([CH2:50][OH:51])[CH2:47]1>>[O:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH:40]1[O:45][CH:46]1[CH2:47][CH:48]([CH2:50][O:51][C:21]([C@@:19]23[CH2:18][N:17]([S:24]([C:27]4[CH:28]=[N:29][C:30]([N:33]5[CH2:37][CH2:36][C@@H:35]([F:38])[CH2:34]5)=[CH:31][CH:32]=4)(=[O:26])=[O:25])[CH2:16][CH2:15][C:14]2=[CH:13][C:12]2[N:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[N:9]=[CH:10][C:11]=2[CH2:20]3)=[O:22])[CH2:49]1

Participants

3

Reactant 2

HCID 66779483[3-(Tetrahydro-pyran-2-yloxy)-cyclobutyl]-methanolHCID 86669995(R)-1-(4-fluorophenyl)-6-[6-((R)-3-fluoropyrrolidin-1-yl)-pyridine-3-sulfonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carbonyl chloride

Product 1

HCID 66779384HCID 66779384, compound

Procedure

The title compound was prepared by the method of Preparation 48b using (R)-1-(4-fluorophenyl)-6-[6-((R)-3-fluoropyrrolidin-1-yl)-pyridine-3-sulfonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carbonyl chloride and [3-(tetrahydro-pyran-2-yloxy)-cyclobutyl]-methanol. LCMS (Method G): 626.6 (M+H)+, Retention time 4.10 minutes.

Sources & evidence

ORD record
ord-75bc91cdee9c4289882b11393314181e
Source dataset
uspto-grants-2013_12
Patent number
US08598154B2

Reaction notes

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