Hydrochloric Acid → HCID 66623754, compound

HRID 1907350Notes

Reaction equation

HRID 1907350 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][C:13]([B:16]4[O:20]C(C)(C)C(C)(C)[O:17]4)=[CH:12][N:11]3[CH:25]=2)=[CH:4][CH:3]=1.Cl.C(OCC)C>CC(C)=O.O>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][C:13]([B:16]([OH:20])[OH:17])=[CH:12][N:11]3[CH:25]=2)=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 44232240HCID 44232240, compound

Product 1

HCID 66623754HCID 66623754, compoundYield 199%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

3.60 g of 2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine are dissolved in 112 ml of acetone and 56 ml of water; 101 ml of 1N hydrochloric acid are added thereto, dropwise and with stirring, and the mixture is stirred at ambient temperature for 24 h. The reaction mixture is then concentrated under reduced pressure. The solid obtained is titurated with diethyl ether and recovered by filtration, and then dried in an oven under reduced pressure at 60° C. 3.12 g of compound are obtained.

Workup

  1. stirringthe mixture is stirred at ambient temperature for 24 h
  2. concentrationThe reaction mixture is then concentrated under reduced pressure
  3. customThe solid obtained
  4. filtrationrecovered by filtration
  5. customdried in an oven under reduced pressure at 60° C

Sources & evidence

ORD record
ord-30be0ce99f91440bb8972150244a7d68
Source dataset
uspto-grants-2013_12
Patent number
US08598166B2

Reaction notes

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