Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

HRID 1907359Notes

Reaction equation

HRID 1907359 reaction equation
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 210731871-(Benzo[b]thiophen-4-yl)piperazine

Product 1

HCID 574825411-(1-Benzothiophen-4-yl)piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Then, 3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the obtained residue and precipitated crystals were obtained by filtration. Recrystallization was performed from methanol to obtain 1-benzo[b]thiophen-4-yl-piperazine hydrochloride as colorless needle-like crystals.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionEthyl acetate was added to the obtained residue
  3. customprecipitated crystals
  4. customwere obtained by filtration
  5. customRecrystallization

Sources & evidence

ORD record
ord-a971fcaa31114f0c819cc15a1e673bd7
Source dataset
uspto-grants-2013_12
Patent number
US08598162B2

Reaction notes

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