Hydrochloric Acid → 2-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt

HRID 1907437Notes

Reaction equation

HRID 1907437 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:6][C:5]=1[NH:17]C(=O)C.[ClH:23]>CCO>[ClH:23].[ClH:23].[ClH:23].[F:22][C:2]([F:1])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:6][C:5]=1[NH2:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59454307N-[2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide

Product 1

HCID 866446602-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-[2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide (4.75 g, 15 mmol) in EtOH (100 mL) was treated with HCl 37% (35 mL). After 1 h under reflux the mixture was concentrated and tritured with hexane to give in quantitative yield, 5.74 g of 2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt.

Workup

  1. temperatureAfter 1 h under reflux the mixture
  2. concentrationwas concentrated and tritured with hexane

Sources & evidence

ORD record
ord-df80f40d6c47484aa340688cefe4ef05
Source dataset
uspto-grants-2013_12
Patent number
US08598172B2

Reaction notes

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