反应详情

温度

200 °C

In a cylindrical quartz tube were placed 4-fluoro-1-methyl-2-nitro-benzene (20.0 g, 129 mmol) and N-methyl-piperazine (26 g, 258 mmol). The reaction was heated for 48 hours at 200° C. until HPLC revealed the disappearance of the starting material. The solvent was removed under reduced pressure and the residue was dissolved in DCM. The solution was washed twice with water and the organic phase was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The final compound (14.65 g, 48% yield) was obtained as a brown oil.

1. customIn a cylindrical quartz tube were placed
2. customThe solvent was removed under reduced pressure
3. dissolutionthe residue was dissolved in DCM
4. washThe solution was washed twice with water
5. dry with materialthe organic phase was dried over anhydrous Na2SO4
6. customthe solvent was removed under reduced pressure