1-(2-Pyrimidinyl)piperazine → HCID 69243666, compound

HRID 1907506Notes

Reaction equation

HRID 1907506 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1.[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:29]2[CH2:30][CH2:31][N:26]([C:21]3[N:20]=[CH:25][CH:24]=[CH:23][N:22]=3)[CH2:27][CH2:28]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 66917958Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate

Product 1

HCID 69243666HCID 69243666, compoundYield 93%

Procedure

Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate and 1-(2-pyrimidyl)piperazine were reacted by the same way with the example 43 to obtain the titled compound (yield, 93%). 1H NMR (300 MHz, CDCl3): δ 2.47 (s, 4H), 3.71 (s, 3H), 3.91-3.99 (m, 4H), 4.13 (s, 3H), 6.53 (s, 1H), 7.01-7.13 (m, 1H), 7.27-7.30 (m, 1H), 7.52-7.61 (m, 2H), 8.33 (d, J=4.8 Hz, 2H).

Sources & evidence

ORD record
ord-9f04a05d54aa4bbaa1109f01b652ab4d
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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