Tetrahydrofuran → [4-(2-Ethyl-5-phenyl-2H-pyrazol-3-yl)-4-oxo-but-2-ynyl]-carbamic Acid Tert-Butyl Ester

HRID 190752Notes

Reaction equation

HRID 190752 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][C:10]#[CH:11].[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:12][CH2:13][CH2:14][CH2:15][Li:16].[CH3:17][O:18][N:19]([C:20](=[O:21])[c:22]1[n:23]([CH2:33][CH3:34])[n:24][c:25](-[c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:26]1)[CH3:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][C:10]#[C:11][C:20](=[O:21])[c:22]1[n:23]([CH2:33][CH3:34])[n:24][c:25](-[c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:26]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 98783462-Ethyl-5-phenyl-2H-pyrazole-3-carboxylic Acid Methoxy-methyl-amideHCID 11073648tert-butyl N-(prop-2-yn-1-yl)carbamateHCID 178418339Butyllithium

Product 1

HCID 10291654[4-(2-Ethyl-5-phenyl-2H-pyrazol-3-yl)-4-oxo-but-2-ynyl]-carbamic Acid Tert-Butyl Ester

Sources & evidence

ORD record
ord-f95810586f7d4d80815f7892fa2fa2f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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