Piperazin-4-ylacetophenone → HCID 69242445, compound

HRID 1907548Notes

Reaction equation

HRID 1907548 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[C:20]([C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)(=[O:22])[CH3:21]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:32]1[CH2:31][CH2:30][N:29]([C:26]3[CH:25]=[CH:24][C:23]([C:20](=[O:22])[CH3:21])=[CH:28][CH:27]=3)[CH2:34][CH2:33]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 97269Piperazin-4-ylacetophenoneHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69242445HCID 69242445, compoundYield 91%

Procedure

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-acetylphenyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 91%). 1H NMR (200 MHz, CDCl3): δ 2.54 (s, 3H), 3.50 (s, 4H), 3.90 (s, 4H), 4.15 (s, 3H), 6.89 (d, J=8.7 Hz, 2H), 7.25-7.62 (m, 3H), 7.79 (s, 1H), 7.91 (d, J=9.0 Hz, 1H).

Sources & evidence

ORD record
ord-14c6d20ead634279abf0f6d6cbb7f0d6
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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