1-(4-Chlorophenyl)piperazine → HCID 69242307, compound

HRID 1907592Notes

Reaction equation

HRID 1907592 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15](=[O:19])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1>>[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15]([N:30]2[CH2:29][CH2:28][N:27]([C:24]3[CH:23]=[CH:22][C:21]([Cl:20])=[CH:26][CH:25]=3)[CH2:32][CH2:31]2)=[O:19])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 974781-(4-Chlorophenyl)piperazineHCID 69243736ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate

Product 1

HCID 69242307HCID 69242307, compoundYield 91%

Procedure

Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(4-chlorophenyl) piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 91%). 1H NMR (300 MHz, CDCl3): δ 2.50 (s, 3H), 3.18-3.28 (m, 4H), 3.73-3.78 (m, 4H), 4.14 (s, 3H), 6.86 (dd, J=12.2 Hz, 2H), 7.00-7.60 (m, 5H), 7.71 (d, J=8.2 Hz, 1H).

Sources & evidence

ORD record
ord-265ef3809cb9475e938fb21dba9a4f03
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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