1-(4-Nitrophenyl)piperazine → HCID 69243999, compound

HRID 1907595Notes

Reaction equation

HRID 1907595 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15](=[O:19])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2.[N+:20]([C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)([O-:22])=[O:21]>>[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15]([N:32]2[CH2:33][CH2:34][N:29]([C:26]3[CH:25]=[CH:24][C:23]([N+:20]([O-:22])=[O:21])=[CH:28][CH:27]=3)[CH2:30][CH2:31]2)=[O:19])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 804471-(4-Nitrophenyl)piperazineHCID 69243736ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate

Product 1

HCID 69243999HCID 69243999, compoundYield 89%

Procedure

Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(4-nitrophenyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 89%). H NMR (300 MHz, CDCl3): δ 2.45 (s, 3H), 3.45-3.60 (m, 4H), 3.76-3.88 (m, 4H), 4.09 (s, 3H), 6.85 (d, J=6.2 Hz, 2H), 7.03-7.68 (m, 4H), 8.16 (d, J=6.0 Hz, 2H).

Sources & evidence

ORD record
ord-2698c2289ec941c7b4485385f9544cd1
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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