N-(2-Cyanophenyl)piperazine → HCID 69244372, compound

HRID 1907615Notes

Reaction equation

HRID 1907615 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16](=[O:20])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2.[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)#[N:22]>>[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16]([N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[C:21]#[N:22])[CH2:34][CH2:33]2)=[O:20])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 2735875N-(2-Cyanophenyl)piperazineHCID 69244324ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69244372HCID 69244372, compoundYield 97%

Procedure

Ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate and 1-(2-cyanophenyl)piperazine were reacted by the same way with the example 148 to obtain the titled compound (yield, 97%). 1H NMR (300 MHz, CDCl3): δ 2.46 (s, 3H), 3.28 (s, 4H), 3.86 (s, 3H), 4.08-4.19 (m, 4H), 7.01-7.08 (m, 3H), 7.17-7.37 (m, 1H), 7.49-7.61 (m, 4H)

Sources & evidence

ORD record
ord-5d86923e54804b6a91433986a7eebfa4
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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