1-(3-Bromophenyl)piperazine → HCID 69241684, compound

HRID 1907651Notes

Reaction equation

HRID 1907651 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][C:7]([O:21][CH3:22])=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[Br:23][C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:27]=[CH:28][CH:29]=1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:33]2[CH2:32][CH2:31][N:30]([C:26]3[CH:27]=[CH:28][CH:29]=[C:24]([Br:23])[CH:25]=3)[CH2:35][CH2:34]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][C:7]([O:21][CH3:22])=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 27571541-(3-Bromophenyl)piperazineHCID 69244380Ethyl N-(2,6,7-trimethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 69241684HCID 69241684, compoundYield 63%

Procedure

Ethyl N-(2,6,7-trimethoxyquinoxalin-3-yl)carbamate and 1-(3-bromophenyl) piperazine were reacted by the same way with the example 190 to obtain the titled compound (yield, 63%) H NMR (300 MHz, CDCl3) δ 3.28-3.30 (m, 4H), 3.78 (m, 4H), 3.97 (s, 3H), 3.99 (s, 3H), 4.13 (s, 3H), 6.86 (m, 1H), 7.01 (s, 1H), 7.06-7.07 (m, 1H), 7.13-7.16 (m, 2H), 7.22-7.28 (m, 2H).

Sources & evidence

ORD record
ord-b85f88bd79db45c0a15aa97c773f1462
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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