Isopropanol → HCID 59737381, compound

HRID 1907724Notes

Reaction equation

HRID 1907724 reaction equation
[OH:1][CH2:2][C:3]1[S:7][C:6]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[C:10]([NH:22][C:23](=[O:36])[C:24]3[CH:29]=[CH:28][C:27]([C:30]4[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=4)=[CH:26][CH:25]=3)[CH:9]=2)=[CH:5][CH:4]=1.C(O)(C)C>C(Cl)Cl>[CH:2]([C:3]1[S:7][C:6]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[C:10]([NH:22][C:23](=[O:36])[C:24]3[CH:25]=[CH:26][C:27]([C:30]4[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=4)=[CH:28][CH:29]=3)[CH:9]=2)=[CH:5][CH:4]=1)=[O:1]

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 59737296HCID 59737296, compound

Product 1

HCID 59737381HCID 59737381, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the same procedure as described in Example 20, step 6 (scheme 20), but substituting compound 190 for compound 199, title compound 200 was obtained in 24% yield [after column chromatography (eluent: 5% isopropanol in DCM)].

Sources & evidence

ORD record
ord-b05af5ba0e9d4a77bfa374c81b99fd9b
Source dataset
uspto-grants-2013_12
Patent number
US08598168B2

Reaction notes

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