Isopropanol → HCID 59737255, compound

HRID 1907726Notes

Reaction equation

HRID 1907726 reaction equation
[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:6]([C:7]([NH:9][C:10]2[CH:11]=[C:12]([C:19]3[CH:24]=[CH:23][C:22]([S:25][CH3:26])=[CH:21][CH:20]=3)[CH:13]=[CH:14][C:15]=2[N+:16]([O-])=O)=[O:8])=[CH:5][CH:4]=1.C([OH:32])(C)C>C(Cl)Cl>[NH2:16][C:15]1[CH:14]=[CH:13][C:12]([C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:26])=[O:32])=[CH:21][CH:20]=2)=[CH:11][C:10]=1[NH:9][C:7](=[O:8])[C:6]1[CH:27]=[CH:28][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 59737282HCID 59737282, compound

Product 1

HCID 59737255HCID 59737255, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the same procedure as described in Example 10, step 2 (scheme 10), but substituting compound 120 for compound 209, the title compound 210 was obtained in 57% yield [after column chromatography (5% isopropanol in DCM)].

Sources & evidence

ORD record
ord-c9d4159010454d04b2449b242ad101aa
Source dataset
uspto-grants-2013_12
Patent number
US08598168B2

Reaction notes

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