反应详情

A solution of triphosgene (0.489 g, 1.61 mmol) in DCM (5 mL) was treated with compound 212 (0.286 g, 1.50 mmol) and the solution was stirred under N2 atmosphere at room temperature for 18 h. The DCM was removed under reduced pressure, the residue was dissolved in pyridin-3-yl methanol (1.0 mL, 10.3 mmol) and the solution was stirred at room temperature for 8 h then diluted with DCM, washed with saturated NaHCO3, H2O, dried over MgSO4, filtered and concentrated to give title compound 213 (0.527 g, 100% yield).

1. customThe DCM was removed under reduced pressure
2. stirringthe solution was stirred at room temperature for 8 h
3. washwashed with saturated NaHCO3, H2O
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated