反应详情

A solution of ester 213 (0.489 g, 1.50 mmol) in 2N HCl (10 mL) was stirred at 110° C. for 3 h then concentrated, suspended in dry acetonitrile (20 mL), stirred for 2 h, diluted with dry benzene (20 mL), and stirred for 6 h. The suspension was concentrated then re-suspended in 1:1 acetonitrile and benzene (20 mL). The solid material was collected by filtration to provide title compound 214 (0.460 g, 88% yield).

1. concentrationthen concentrated
2. additiondiluted with dry benzene (20 mL)
3. stirringstirred for 6 h
4. concentrationThe suspension was concentrated
5. filtrationThe solid material was collected by filtration