Potassium Hydroxide → HCID 59737573, compound

HRID 1907729Notes

Reaction equation

C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)=[CH:11][C:10]=1[NH:20][C:21]([C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]([C:33]([O:35][CH2:36][C:37]1[CH:38]=[N:39][CH:40]=[CH:41][CH:42]=1)=[O:34])[CH2:28][CH2:27][CH2:26]2)=[O:22])=O)(C)(C)C.C([O-])(O)=O.[Na+].[OH-].[K+]>>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)=[CH:11][C:10]=1[NH:20][C:21]([C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]([C:33]([O:35][CH2:36][C:37]1[CH:38]=[N:39][CH:40]=[CH:41][CH:42]=1)=[O:34])[CH2:28][CH2:27][CH2:26]2)=[O:22]

Participants

Reactant 3

HCID 14797Potassium Hydroxide

HCID 516892Sodium Bicarbonate

HCID 59737341HCID 59737341, compound

Product 1

HCID 59737573HCID 59737573, compoundYield 89%

Procedure

Following the same procedure as described in Example 1, step 7 (scheme 1), but substituting compound 8 for compound 215, and NaHCO3 for KOH, the title compound 216 was obtained in 89% yield.

Sources & evidence

ORD record: ord-17263b4d093f49b2a95ab7489a7fcac2
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598168B2

Reaction notes

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