HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzoic acid, 4-(acetyloxy)- → 4-(2-(tert-Butoxycarbonylamino)-5-(3-oxocyclopent-1-enyl)phenylcarbamoyl)phenyl acetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzoic acid, 4-(acetyloxy)- | HCID 16865 | — |
| Edukt | (R)-4-((3-(Dimethylamino)pyrrolidin-1-yl)methyl)benzoic acid | HCID 59737509 | — |
| Edukt | tert-Butyl 2-amino-4-(3-oxocyclopent-1-enyl)phenylcarbamate | HCID 59737590 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 4-(2-(tert-Butoxycarbonylamino)-5-(3-oxocyclopent-1-enyl)phenylcarbamoyl)phenyl acetate | HCID 59737207 | 30% |
Reaktionsschritte
Following the same procedure as described in Example 1, step 6 (scheme 1), but substituting compound 4 for compound 258 and compound 7 for 4-acetoxybenzoic acid, title compound 259 was obtained as a yellow oil in 30% yield [after flash chromatography (eluent: 30% AcOEt in hexanes)].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08598168B2 |
| Quelldatensatz | uspto-grants-2013_12 |
| ORD ID | ord-a748e2e81107472e93512be78f086a1c |
| Quellennotiz | uspto-grants-2013_12 |