Potassium Hydroxide → HCID 59737523, compound

HRID 1907748Notes

Reaction equation

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[CH2:15][CH2:14]/[C:13](=[CH:16]\[CH:17]=[CH:18]\[C:19]([NH:21][C:22]4[CH:27]=[C:26]([C:28]5[S:29][CH:30]=[CH:31][CH:32]=5)[CH:25]=[CH:24][C:23]=4[NH:33]C(=O)OC(C)(C)C)=[O:20])/[CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1.C(=O)(O)[O-].[Na+].[OH-].[K+]>>[NH2:33][C:23]1[CH:24]=[CH:25][C:26]([C:28]2[S:29][CH:30]=[CH:31][CH:32]=2)=[CH:27][C:22]=1[NH:21][C:19](=[O:20])/[CH:18]=[CH:17]/[CH:16]=[C:13]1/[CH2:12][N:11]([CH2:10][C:8]2[CH:7]=[CH:6][C:5]3[O:1][CH2:2][O:3][C:4]=3[CH:9]=2)[CH2:15][CH2:14]/1

Participants

Reactant 3

HCID 14797Potassium Hydroxide

HCID 516892Sodium Bicarbonate

HCID 59737541HCID 59737541, compound

Product 1

HCID 59737523HCID 59737523, compound

Procedure

Following the same procedure as described in Example 1, step 7 (scheme 1), but substituting compound 8 for compound 277 and sodium bicarbonate with potassium hydroxide, the title compound 278 was obtained in quantitative yield.

Sources & evidence

ORD record: ord-a5bce111689641d08a2ba4e6f8eaf360
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598168B2

Reaction notes

Loading…