HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1907749Generated: October 29, 2026
3-Pyridinemethanol → 4-((Pyridin-3-ylmethoxy)carbonylamino)benzoic acid
https://huagongshe.com/reaction/1907749
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Pyridinemethanol | HCID 7510 | — |
| Reactant | Ethyl 4-isocyanatobenzoate | HCID 589805 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-((Pyridin-3-ylmethoxy)carbonylamino)benzoic acid | HCID 59737331 | 96% |
Reaction Steps
A solution of ethyl 4-isocyanatobenzoate 280 (2.0 g, 10.46 mmol) and pyridin-3-ylmethanol in THF was stirred at room temperature for 18 h then concentrated. The crude material was taken up in 2N HCl, heated to reflux for 16 h then cooled to −78° C. and lyophilized to give a solid material which was triturated with acetone to give title compound 281 (3.098 g, 96% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598168B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-f6a6850b80ab4c30b7ec4d1d1e15db4c |
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| Source note | uspto-grants-2013_12 |
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